Age‐dependent decline of nigrostriatal dopaminergic function: A positron emission tomographic study of grandparents and their grandchildren
Identifieur interne : 004281 ( Main/Exploration ); précédent : 004280; suivant : 004282Age‐dependent decline of nigrostriatal dopaminergic function: A positron emission tomographic study of grandparents and their grandchildren
Auteurs : Michael Cordes [Allemagne] ; Michael Snow [Canada] ; Sandra Cooper [Canada] ; Michael Schulzer [Canada] ; Brian D. Pate [Canada] ; Thomas J. Ruth [Canada] ; Donald B. Calne [Canada]Source :
- Annals of Neurology [ 0364-5134 ] ; 1994-10.
Abstract
Despite postmortem evidence for an age‐related decline in nigrostriatal dopaminergic function, positron emission tomography (PET) studies have produced inconsistent results. This may be due to differences inmethods or of subject selection. To investigate further the effect of age on dopaminergic function, we performed PET with 6‐L‐[18F]fluorodopa (FD) on 12 pairs of grandchildren and their grandparents. The FD uptake rate constant (Ki) was calculated using a graphical method for the whole striatum to avoid confounding of the results by striatal atrophy. The mean Ki was significantly lower in grandparents (p = 0.020). These PET observations represent in vivo confirmation of postmortem evidence that nigrostriatal dopaminergic function declines with aging.
Url:
DOI: 10.1002/ana.410360420
Affiliations:
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This may be due to differences inmethods or of subject selection. To investigate further the effect of age on dopaminergic function, we performed PET with 6‐L‐[18F]fluorodopa (FD) on 12 pairs of grandchildren and their grandparents. The FD uptake rate constant (Ki) was calculated using a graphical method for the whole striatum to avoid confounding of the results by striatal atrophy. The mean Ki was significantly lower in grandparents (p = 0.020). These PET observations represent in vivo confirmation of postmortem evidence that nigrostriatal dopaminergic function declines with aging.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Cordes, Michael" sort="Cordes, Michael" uniqKey="Cordes M" first="Michael" last="Cordes">Michael Cordes</name></region></country><country name="Canada"><noRegion><name sortKey="Snow, Michael" sort="Snow, Michael" uniqKey="Snow M" first="Michael" last="Snow">Michael Snow</name></noRegion><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B." last="Calne">Donald B. Calne</name><name sortKey="Cooper, Sandra" sort="Cooper, Sandra" uniqKey="Cooper S" first="Sandra" last="Cooper">Sandra Cooper</name><name sortKey="Pate, Brian D" sort="Pate, Brian D" uniqKey="Pate B" first="Brian D." last="Pate">Brian D. Pate</name><name sortKey="Ruth, Thomas J" sort="Ruth, Thomas J" uniqKey="Ruth T" first="Thomas J." last="Ruth">Thomas J. Ruth</name><name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name><name sortKey="Snow, Michael" sort="Snow, Michael" uniqKey="Snow M" first="Michael" last="Snow">Michael Snow</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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